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1.
2nd International Conference for Innovation in Technology, INOCON 2023 ; 2023.
Article in English | Scopus | ID: covidwho-2326348

ABSTRACT

In today's post-covid culture, where everyone works from home, there is a huge possibility of serious long-term health problems. A lot of people have started taking up exercises at home and if done incorrectly, they can have major negative effects. Another one of the main contributors to these health issues is bad sitting posture, which is only exacerbated when working for hours on end. Hand gesture detection has many useful applications in elderly healthcare, automating actions and gesture-based presentations and games. To help users with these actions, our paper proposes pinpointing the points of the error to the user in real-time and in a lightweight manner for yoga posture correction. The incorrect positions shall be shown in real-time on top of the user's video feed to help them correct it properly. The user shall be told about when they are sitting in a bad position, and the overall bad posture time will also be shown for the session, which will provide the required information to the user. To further help users in a useful manner, our paper looks to augment the hand gesture detection feature with federated learning and personalization to avoid the common pitfall of privacy concerns, while still allowing users to customize their experience. The proposed library for the implementation of these tasks is the MediaPipe library. This library is one of the key components that makes the features lightweight and easy to use. The aforementioned library also looks to implement the features in real time with no lag while keeping the resource requirements as low as possible. © 2023 IEEE.

2.
1st International Conference on Software Engineering and Information Technology, ICoSEIT 2022 ; : 156-161, 2022.
Article in English | Scopus | ID: covidwho-2277410

ABSTRACT

The blood Transfusion Unit of the Indonesian Red Cross (UTD PMI) Pontianak is an organization engaged in blood donation services. During the COVID-19 pandemic, the bloodstock at UTD PMI Pontianak was insufficient. When the bloodstock was insufficient, donor seekers or the families of patients who needed blood would share messages asking for blood on social media. However, people often ignored these messages because they were not addressed to the right donor, as well as donors who often see similar messages but do not match their blood type. One of the factors that caused insufficient bloodstock at UTD PMI Pontianak was the lack of donor motivation in donating blood. The existing blood donor application still had some problems regarding the user interface, and there were still some users' needs that had not been met in the application. For a design to meet the users' needs, the researchers used the User-Centered Design (UCD) method to create a user interface for blood donation information media because UCD focused on user needs to achieve user goals. The prototype was tested for usability using the USE Questionnaire and follow-up interviews. From the results of the USE Questionnaire, the researchers obtained very good usability for every aspect, with a score above 92%. This research also showed that donors and donor seekers felt helped by the prototype of blood donor information media because it could meet the user needs in dealing with the problem they faced. © 2022 IEEE.

3.
Cardiometry ; - (24):877-886, 2022.
Article in English | Web of Science | ID: covidwho-2204497

ABSTRACT

The purpose of this study is to identify the factors that aid in the measurement of the effectiveness of consumer promotions in brick-and-mortar retail. The already highly competitive landscape of retail is set to undergo a huge transformation post the COVID-19 outbreak, which will inadvertently lead to manufacturing cutting down costs wherever possible to maintain their margins and stay afloat. Advertising spends are bound to go down, and there is a need for a statistical model to measure the effectiveness of the capital spends by a firm towards consumer promotions. For the study, national level sales data of 4 sub-brands of a particular toilet soap brand (shower soap bars) was analyzed for a leading retail chain in India from January 2018 to February 2020. Regression analysis was used to do the data analysis. The study focused on price-off consumer promotions only for the designated period for four variants of a popular Indian soap brand. The discount percentage (including both promotion spend by the manufacturer as well as a retailer), the quantity of the particular unit sold on which the promotion was run during the period when the promotion was run, the effective price to consumer per gram, and profitability for the manufacturer in terms of the net contribution percentage were the factors which were found to show a strong correlation and formed the input variables for the regression equation. The regression analysis showed that all the factors, namely: overall discount percentage, quantity sold, the effective price per gram, and the net contribution (profitability), were statistically significant in determining the uplift in sales quantity due to the discount (the effectiveness of the price promotion). The equation provides retailers and manufacturers a model to measure the effectiveness of promotion spending for price promotions that are run every month at a national and state level by giving state-level values as inputs. It also helps arrive at a baseline sales quantity for a particular SKU if no price-off promotion is run.

4.
Jindal Global Law Review ; 2022.
Article in English | Scopus | ID: covidwho-2158246

ABSTRACT

Gerontology—the multidisciplinary study of the process of ageing and its medical and social consequences for older adults—has often not been given its due by either legal practitioners or legal academics. While we have witnessed several social movements advocating for the rights and interests of other marginalised groups, discrimination against older adults has also not been the subject of any mass action comparable to those movements. Consequently, the position of older adults within legal systems has frequently been bypassed, especially outside the United States of America. However, the COVID-19 pandemic suddenly brought the precarious position of older adults into the spotlight, be it in care homes during lockdowns or in hospitals through several waves or with regard to priority access to vaccines. At each juncture, governments took recourse to legal regulation to mitigate the impact of the disease on what they understood to be the most vulnerable sections of the population. But some of these rules were subjected to criticism, especially from older adults themselves, because of their overbreadth, and on account of the protectionism and infantilisation of older adults that they entailed. In this interview, Professor Israel (Issi) Doron, Dean of the Faculty of Social Welfare and Health Sciences of the University of Haifa, Israel, discusses how academia, strategic litigation, and advocacy and activism have finally begun taking the field of ‘jurisprudential gerontology' into serious consideration. © 2022, The Author(s).

5.
Journal of the Intensive Care Society ; 23(1):42-43, 2022.
Article in English | EMBASE | ID: covidwho-2043022

ABSTRACT

Introduction: Recruitment in intensive care has long been discussed, with the pandemic bringing this into sharp focus. Most anaesthetists in training were fully redeployed into ICU rotas or provided technical expertise. As surge rotas settle and a 'new normal' is regained, the challenge of ICU consultant recruitment needs to be addressed. Historically, ICUs have been predominantly staffed by consultants trained in both anaesthetics and intensive care medicine (ICM), but the challenges of this career path have been augmented by COVID-19. Forecasts suggest a concerning supply shortage of both anaesthetic and ICM consultants.1 The latest recruitment round for ICM has been the most competitive year for applications (ratio 2.9:1 in 2021 compared to 1.49:1 in 2020).2 However, the anaesthetic/ICM dual-training contribution to this workforce has worryingly decreased from approximately twothirds to less than a half. But what factors are causing this and has COVID-19 redeployment worsened this? Objectives: As we emerge from the second wave of the pandemic, we assessed the attitudes of anaesthetists about future careers in intensive care. Methods: We performed a brief electronic survey of 100 dual-or single-specialty anaesthetists in training from four LETBs across England who were redeployed to ICU. Results: Our survey showed that 29% had a negative experience that dissuaded them from pursuing ICM careers or, in some circumstances, relinquish their ICM training number altogether. Promisingly, 64% had a positive experience, and of these 39% reaffirmed their desire to pursue a career in ICU and 13% developed a new interest in pursuing a career in ICU since their redeployment. Positive factors included, 'teamwork', 'complexity of patients' and 'adding variety to my anaesthetic practice'. Prominent negative factors were 'additional exams', 'two separate portfolios' and 'high risk of burnout'. Respondents suggested changes to attract more anaesthetists to dual-accredit with ICM. This included the removal of hurdles such as additional exams, separate portfolios, and duplicated assessments. The additional training time was also highlighted, particularly given that trainees already contribute significantly to ICM rotas. There was a need for more flexibility in training with dual trainees wanting to undertake advanced training modules like their anaesthetic counterparts. They also reported wanting more anaesthetic sessions in their future job plans possibly reflecting the desire for varied practice as a consultant. Conclusion: Although COVID-19 has had a positive effect by increasing ICM applications, this may be at the expense of dual-trained anaesthetic/ICM trainees. FFICM should consider the factors which dissuade these applicants and its future impact on skills available in ICU. Both the RCoA and the FFICM have recently announced changes to curricula and e-portfolio which may close some of these gaps. The pandemic has grabbed the attention of a few anaesthetists and presented an opportunity to work in a team that solves difficult physiological puzzles, rapidly escalates capacity, and increasingly focuses on staff wellbeing. We should capitalise on this and hope that COVID-19 will result in the conversion of some of our anaesthetic colleagues into dual-specialty ICM consultants.

6.
NeuroQuantology ; 20(10):855-860, 2022.
Article in English | EMBASE | ID: covidwho-1998072

ABSTRACT

Background:The present coronavirus-related epidemic of respiratory and upper respiratory infections (SARS CoV-19) has worldwide mortality and morbidity. This study evaluated the awareness and attitudes of undergraduate medical students concerning the 2019-novel Corona virus. Materials & Methods:235 participants were taken into account subsequent to receiving informed written consent. The questionnaire consisted of Demographic profile, Information Regarding Source of Knowledge, awareness questions and attitude-based questions. Results: Out of 235 subjects, males were 110 and females were 125. Correct response in reference to questionnaire were you diagnosed with covid-19,if yes then specify the method of diagnosis was given by 78%, how does COVID-19 transmit by 85%, how satisfied are you with the amount of health information available about COVID-19 by 86%, how do you mainly obtain health information by 90%, can COVID-19 be cured with antibiotics by 94%, what is the main test to be done for covid 19 by 88%, which organ mainly gets effected in covid-19 by 94%, how confident are you in your own hospital to diagnose or recognize COVID-19 by 90%, please rate your likelihood of contracting COVID-19 during the current outbreak by 91%, please rate your likelihood of surviving COVID-19 if infected by 78%, please rate your concerns about other family members getting COVID-19 by 82%, which type of mask did you buy during the pandemic by 86%, do you think country's health department is doing enough to prevent the outbreak from spreading by 88%, do you think your country's health department is doing enough to cure those infected by 90%, do you cover your mouth while coughing and sneezing by 85% and do you avoid sharing utensils by 89%. Conclusion: Undergraduate medical students possessed adequate awareness and attitude towards 2019-novel Corona virus.

8.
24th International Conference on Advanced Communication Technology, ICACT 2022 ; 2022-February:483-490, 2022.
Article in English | Scopus | ID: covidwho-1789861

ABSTRACT

Regarding the rapid spread of Covid-19 in Indonesia, the Ministry of Health of Indonesia has developed an e-HAC (Electronic-Health Alert Card) application to reduce the risk. That mobile application has a purpose to detect, prevent, and control public health emergencies through point of entries. Besides, the users of the e-HAC application have trouble on using the application. The issues are specifically on navigation between the menus, and the lack of aesthetics and appealing of user interface. Those issues lead to the main purpose of this research, which is to upgrade the interface design of e-HAC application to a suitable User Interface by using User-Centered Design (UCD) method. There are also specific objectives: first is to conduct usability testing in form of questionnaires and interview two times: one is a pre-survey, to evaluate the problems of the e-HAC application based on user experience;and the another one is a post-survey, to find out whether the upgraded design that has been made can ease the users to access the e-HAC application. Then, the second specific objective is to implement the System Usability Scale (SUS) method for measuring the system usability based on questionnaires. After the implementation of the UCD method, the researcher re-surveyed and obtained a test scores of SUS, from 53.87 previously to, 85.12. That means the acceptability ranges that were originally Low changed to Acceptable. Moreover, for the Grade Scale, which was originally D into category B. © 2022 Global IT Research Institute-GiRI.

9.
2021 International Conference on Computer Science, Information Technology, and Electrical Engineering, ICOMITEE 2021 ; : 154-161, 2021.
Article in English | Scopus | ID: covidwho-1700626

ABSTRACT

Webinars have been widely used in the education before the COVID-19 pandemic due to the application development in the face-to-face learning process. When someday the pandemic ends, will the habit of using webinar technology also end? This study aims to examine what factors influence participants to continue using webinars during the new normal. The conceptual model was built using the Stimulus-Organism-Response (S-O-R) theory, involving 429 respondents. Their quantitative perceptions were processed using PLS-SEM assisted by Smart PLS 3.3.2 software. Factors that influence Satisfaction (SAT) and Perceived Usefulness (USE) are Perceived Enjoyment (ENJ), Perceived Ease of Use (EOU), Perceived Security (SEC), and Perceived Content Quality (QUA) while Webinar Application Continuous Intention (CONT) factor are influenced by Social Influence (INF), Satisfaction (SAT), and Perceived Usefulness (USE). Thus, the webinar application will continue to be used together with the face-to-face method, which will be opened gradually. © 2021 IEEE.

10.
Journal of Urology ; 206(SUPPL 3):e616-e617, 2021.
Article in English | EMBASE | ID: covidwho-1483633

ABSTRACT

INTRODUCTION AND OBJECTIVE: COVID-19 has been a disruptive pandemic that has transformed the landscape of the health care system. The pandemic disproportionately affects patients from a racial diverse and economic depressed demographic, highly represented in Newark (Essex County, NJ). We seek to investigate how the COVID-19 pandemic has affected the flow of patients to an inner-city health care system, specifically a major academic urology clinic in Newark, NJ. METHODS: We collected de-identified data for clinic volume and appointment no-show rates from the electronic medical record from September 16, 2019 to January 26, 2021. Publicly available data on COVID cases and death rates in Essex county was collected from public data reporting on March 4, 2020 to January 31, 2021. Data analysis and statistical analysis was performed with Jupyter Notebooks and Microsoft Excel. RESULTS: The number of patients who were no-shows was significantly correlated with daily COVID cases (-0.49, p=0.004). The total number of clinic patients was also less when there were higher COVID cases (-0.41, p=0.02). We found that the rate of no-shows and the daily reported COVID cases was weakly correlated (-0.33, p=0.06). The number of daily deaths from COVID-19 was not statistically correlated with clinic flow. Overall, we found that during the COVID pandemic our no-show rate averaged 25.4±0.093% compared to 25.9±0.065% prior to March 4, 2020. CONCLUSIONS: The total clinic volume and total number of no-show patients was significantly decreased on days with higher reported COVID-19 cases in Essex county. Reported COVID-19 deaths did not correlate with clinic flow. Future research is planned for looking at specific patient demographic data such as race/ ethnicity, language, socioeconomic status, and diagnosis. We will also evaluate whether the no show rate significantly delayed health care for these patients and affected their prognosis.

11.
International Journal of Obstetric Anesthesia ; 46, 2021.
Article in English | EMBASE | ID: covidwho-1333518

ABSTRACT

Introduction: It is estimated that needle phobia is present in up to 10% of the population.1 We present the antenatal anaesthetic management of a pregnant woman initially refusing any blood tests or cannulation but ultimately requiring emergency caesarean delivery. Case Report: The high risk antenatal anaesthetic clinic became aware of a 26-year-old woman (G1P0) of 30 weeks’ gestation with extreme needle phobia. She had no medical history, the pregnancy was low risk and a midwifery-led delivery was planned. The woman declined blood tests in pregnancy. We met the woman with her community midwife. She stated she would run for the hills rather than have a cannula or would lock herself in the bathroom if the need arose. She was indifferent on hearing that a cannula is required for anaesthesia or that refusing one may be life-threatening. Her phobia possibly stemmed from a childhood experience but she had no recall of this. Although sceptical, the woman worked with us on a multifaceted plan. We emphasised the importance of her engagement. A referral for cognitive behavioural therapy failed due to the Covid-19 pandemic. Instead we suggested hypno-birthing techniques and mindfulness apps to manage anxiety. We taught applied tension although doubtful of its use as the woman did not suffer vasovagal symptoms with her phobia. We described graded exposure and gave resources, however she did not manage any of these. We devised distractions involving her partner and media, for example FaceTiming her mother and using headphones to listen to music or watch videos. We asked her to work on positive visualisation, focusing on gains, empowerment and rewards. Medical strategies were planned, specifically topical anaesthesia before cannulation and Entonox. In the event of an emergency caesarean we ruled out inhalational induction before cannulation. In turn, we agreed to be empathetic to her phobia and respect her choices. We agreed to minimise interventions but would not be influenced into deviating from safe protocol. Following initial consultation we remained in telephone contact. She remained unsure if she would consent. Hospital legal services were contacted for advice and a discussion with a QC was arranged. We were advised to create advance consent documents to avoid applying to the courts. After a few hesitant weeks the woman turned a corner and the community midwife reported improvement in mindset. We discussed the legal paperwork but the woman decided it was not necessary. An action plan was attached to her notes. Ultimately she required a cannula for antibiotics, induction of labour, epidural and caesarean delivery under epidural top-up. She was compliant and coped by using varying degrees of the above outlined strategies. On follow-up in the community the midwifery team reported a happy mother looking forward to future pregnancies and being able to keep her phobia under check. Discussion: This case demonstrates the importance of developing a management plan for the extreme needle phobic parturient. A pregnant woman’s greatest fear was controlled in order to facilitate safe delivery.

12.
Obesity Facts ; 14(SUPPL 1):193, 2021.
Article in English | EMBASE | ID: covidwho-1255727

ABSTRACT

Objective: Elderly age is documented as the highest risk factor for the requirement of intensive care in COVID-19 patients. Diabetes and obesity are the risk enhancers in COVID-19. However, there is limited evidence for the modifiable risk factors like body weight as a predictor for the need for Intensive Care Unit (ICU) care in T2DM patients. We evaluated the association of body weight as a predictor of ICU admissions Methods: We evaluated 187 patients T2DM patients (111 males, 76 females), recovered from COVID-19, on follow up for diabetes care, from eight diabetes clinics who had association of the metabolic risk factors with the need for intensive care. Descriptive statistics and Fisher's exact test were performed Results: There were 100 known hypertensives and 140 patients recovered without intensive care. The mean age (years), BMI (kg/m2), HbA1c (%), was 56 (±14, minimum 11, maximum 94, range 83, 95% CI 55 to 58), 27 (±4.7, minimum 17, maximum 44, range 83, 95% CI 27 to 28), 8.1 (±1.6, minimum 4.8, maximum 15, range 10, 95% CI 7.9 to 8.4), respectively. 50 patients (26.7%) at follow up, for diabetes consultation, post COVID-19 had good glycemic control, with HbA1c of less than 7%. 47/187 (25.1%) of the T2DM needed ICU care. 79 (42.2%) patients were age ≥60. Higher proportion with age ≥60, 30.3% (n = 24) required ICU as compared to 21.2% (n = 23) out of 108 patients with age < 60, (relative risk = 1.42, p = 0.17 NS). 125 (66.8%) patients were either overweight or obese (BMI ≥25 kg/m2). Higher proportion with BMI ≥25, 27.2% (n = 34) required ICU as compared to 20.9% (n = 13) out of 62 patients with BMI < 25 kg/m2 (relative risk = 1.29, p = 0.37 NS). Th most frequent associated morbidities in T2DM were, overweight-obesity (n = 125), followed by hypertension (n = 100) and Chronic Kidney Disease (CKD) (n = 12) Conclusion: ICU admission risk was elevated for both elderly age and overweight - obese patients in T2DM patients diagnosed with COVID-19. Our findings reinforce risk imposed by obesity-related metabolic derangements leading to systemic metabolic inflammation (metaflammation). We postulate the need to manage the burden of obesity to reduce the severity of COVID-19. Reduction of body weight would help to mitigate the need of ICU care and free the limited healthcare resources that are already constrained due to COVID-19 and has the potential to improve the outcomes.

13.
Journal of the American Geriatrics Society ; 69:S216-S216, 2021.
Article in English | Web of Science | ID: covidwho-1195007
14.
Journal of the American Geriatrics Society ; 69:S105-S105, 2021.
Article in English | Web of Science | ID: covidwho-1194983
15.
Education Sciences ; 11(3), 2021.
Article in English | Scopus | ID: covidwho-1186907

ABSTRACT

Due to the COVID-19 pandemic, most educational institutions across the world have shifted their teaching and learning processes and put efforts into preparing online distance education to ensure education continues uninterrupted. Some did not face difficult tasks or challenges during this process because they were already implementing online or blended learning before the pandemic. However, some institutions, lecturers and students were not ready to adapt to the conditions, and it is therefore important to examine to what extent lecturers are ready to teach online. This research aims to evaluate the readiness of lecturers during a pandemic that arises unexpectedly. It also aims to investigate the weaknesses and obstacles that lecturers must overcome in order to teach an online class. This research applies a mixed-method approach. Lecturers were surveyed through online preparedness questionnaires, and several themes were constructed from the gathered qualitative data. The results show that lecturers have strong baseline technical skills to use e-learning platforms for online courses;they have quickly adapted to using a Learning Management System (LMS), and most have a tactical solution for most online classes with insufficient feasibility, but they do not have a strategic solution. Their sufficiency for teaching online courses was not optimised since they did not fully believe the learning goals could be achieved. This paper elaborates on the theoretical and practical implications. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

16.
Annals of the Romanian Society for Cell Biology ; 24(2):153-164, 2020.
Article in English | Scopus | ID: covidwho-1063793

ABSTRACT

Predictions, without mathematical approach and statistics appear bogus and simply drawn out of air. Hence applicability of mathematical modelling paves way for more authentic approach, the complexity of which depends on the number of parameters incorporated for use in the model. Analysing this, our work involved development of a model, labelled as SIQTRD model, which will signify its role and comprehensiveness in role prediction of quarantine in future containment of Covid19 disease as well as gain insights into the dynamics of disease transmission, based on the data available within a certain time frame. Predictions done this way in understanding the emergence effect and containment of epidemic are more effective and foster hind casting the event. The model predicts the number of active cases to reach 90,000-2,90,000 in India by mid-May to late June. In fact when the virus will enter the plateau phase, the number of active cases may monotonically increase even more depending on the relaxations implemented in lockdown and quarantine approach. This will be followed by a decreasing trend in the number of peak infective cases towards end August and after this the virus will fade out eventually although after effects may be visible in coming years. However the recovery rate may show an increasing trend due to the lockdown and quarantine policies in place providing ample time to the scientists, visionaries and medical practitioners to adopt implement and deploy anti-epidemic procedures including development of vaccines, testing kits etc. which will help out in dimming the disease. © 2020, Universitatea de Vest Vasile Goldis din Arad. All rights reserved.

17.
Journal of Cardiac Critical Care ; 4(1):47-50, 2020.
Article in English | EMBASE | ID: covidwho-990051

ABSTRACT

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) virus has spread quickly and become a public health emergency of global concern. Originating in the Wuhan district of China, which has reportedly been declared free of it now, the rest of the world continues to struggle with its severity and spread. While a lot of scientific publications and clinical data are available, newer clinical investigations and experiences continue to evolve, thereby depicting the dynamic nature of the disease and the knowledge around it. Researchers and clinical professionals continue to collect scientific information, clinical data, and evidence to help build a knowledge pool and guidance for the health care professionals to manage those affected with this pandemic disease. As significant and new data emerge, a lot of already available information gets confirmed and updated, while some of it also getting rejected or disapproved. In this article, we aim to put together the scientific and clinical information that is proven so far and the areas where more data or evidence is needed before a clear understanding can be achieved and guidance can be developed.

18.
National Journal of Physiology, Pharmacy and Pharmacology ; 10(9):795-798, 2020.
Article in English | EMBASE | ID: covidwho-769682

ABSTRACT

Background: Coronavirus disease-2019 (COVID-19) was declared a pandemic by the WHO (WORLD HEALTH ORGANIZATION), on March 11, 2020. There is no doubt in the fact that this infection has marked its great effects on various aspects of one’s life, may it be a personal, familial, social, economic, psychological, academic, professional, financial, emotional, either directly or indirectly. At present, a number of studies are being done so as to study the impact of coronavirus on the different spheres of our life, either directly affecting their own heath or of family members, or indirectly, by influencing thorough lockdowns, quarantine, or isolation. Aims and Objectives: Due permission was taken from the screening ethical committee. Thereafter, this study was conducted on the students of medical, dental and nursing courses, in our institute, as these three professions are the only ones that are at the frontline as far as provision of health-care services to the public is concerned. Materials and Methods: This was a cross-sectional study that was carried out on undergraduate students of three courses from our own university, i.e., M.B.B.S, B.D.S., and B.Sc. Nursing. The participation was only voluntarily. The subjects were asked a questionnaire, including 18 questions regarding the impact of this corona infection on their personal and academics part of their life. Results: According to the results of this online study, this infection has markedly affected the personal and academics of these students as they are attending lectures through online mode only, but even then the majority of them are really much determined to continue pursuing their respective courses. Conclusion: Throughout the world, right now, no specific treatment is available for this infection, though a number of researches are being carried out to know about this novel virus, its characteristic features in details, response to various drugs and vaccines that are now undergoing a number of trials, everywhere in the world.

19.
SAR QSAR Environ Res ; 31(9): 643-654, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-733459

ABSTRACT

A quantitative structure-activity relationship (QSAR) model was built from a dataset of 54 peptide-type compounds as SARS-CoV inhibitors. The analysis was executed to identify prominent and hidden structural features that govern anti-SARS-CoV activity. The QSAR model was derived from the genetic algorithm-multi-linear regression (GA-MLR) methodology. This resulted in the generation of a statistically robust and highly predictive model. In addition, it satisfied the OECD principles for QSAR validation. The model was validated thoroughly and fulfilled the threshold values of a battery of statistical parameters (e.g. r 2 = 0.87, Q 2 loo = 0.82). The derived model is successful in identifying many atom-pairs as important structural features that govern the anti-SARS-CoV activity of peptide-type compounds. The newly developed model has a good balance of descriptive and statistical approaches. Consequently, the present work is useful for future modifications of peptide-type compounds for SARS-CoV and SARS-CoV-2 activity.


Subject(s)
Antiviral Agents , Betacoronavirus/drug effects , Peptides , Quantitative Structure-Activity Relationship , Antiviral Agents/chemistry , Antiviral Agents/pharmacology , Betacoronavirus/enzymology , Coronavirus 3C Proteases , Cysteine Endopeptidases , Inhibitory Concentration 50 , Linear Models , Molecular Structure , Peptides/chemistry , Peptides/pharmacology , SARS-CoV-2 , Viral Nonstructural Proteins/antagonists & inhibitors
20.
National Journal of Physiology, Pharmacy and Pharmacology ; 10(8):657-662, 2020.
Article in English | EMBASE | ID: covidwho-714594

ABSTRACT

Background: Stress is the physiological and psychological state which could overwhelmed an individual’s capacity to adequately respond to it. The coronavirus disease (COVID 19) outbreak in India had created a sudden shutdown of conventionally designed medical teaching, because of which the medical students were in a stage of dilemma. The new digital e-learning methods psychologically affected these students invariably. Aim and Objective: We hypothesized that significant stress was associated with non-use of digital online e-learning as well as lack of communication between teachers and students. Materials and Methods: After the institutional ethical clearance, this online survey study was done on medical students. A total of 924 students participated in the study. All the students voluntarily participated in the survey based on perceived stress scale (PSS) (ten items). The PSS-10 is used to compare the stress level in between Group I who was using digital e-learning methods and Group II who was not using digital e-learning methods. Results: The PSS-10 score was significantly high in the group who was not using digital online e-learning methods during this COVID 19 pandemic lockdown. Conclusion: The perception of perceived stress is high among the medical students who were not using online digital e-learning approaches. More research is needed to identify potential confounders.

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